新型氟喹诺酮CP-99,219对淋病奈瑟菌菌株的体外活性
In vitro activity of a new fluoroquinolone, CP-99,219, against strains of Neisseria gonorrhoeae.
作者信息
Knapp J S, Neal S W, Parekh M C, Rice R J
机构信息
Division of Sexually Transmitted Diseases Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
出版信息
Antimicrob Agents Chemother. 1995 Apr;39(4):987-9. doi: 10.1128/AAC.39.4.987.
Abstract
The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and 0.03 microgram/ml, respectively. For strains for which the MICs of ciprofloxacin were 0.125 to 0.5 microgram/ml, the MIC90s of CP-99,219, ciprofloxacin, and ofloxacin were 0.06, 0.25, and 0.5 microgram/ml, respectively. For strains for which the MICs of ciprofloxacin and ofloxacin were 2.0 micrograms/ml, the MIC of CP-99,219 was 0.25 microgram/ml.
摘要
测定了216株淋病奈瑟菌对一种新型氟喹诺酮类药物CP-99,219的敏感性。对于环丙沙星最低抑菌浓度（MIC）≤0.06微克/毫升的菌株，CP-99,219、环丙沙星和氧氟沙星使90%分离株受到抑制的最低抑菌浓度（MIC90）分别为0.008、0.015和0.03微克/毫升。对于环丙沙星MIC为0.125至0.5微克/毫升的菌株，CP-99,219、环丙沙星和氧氟沙星的MIC90分别为0.06、0.25和0.5微克/毫升。对于环丙沙星和氧氟沙星MIC为2.0微克/毫升的菌株，CP-99,219的MIC为0.25微克/毫升。
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