Rice R J, Knapp J S
Division of Sexually Transmitted Diseases Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
Antimicrob Agents Chemother. 1994 Jan;38(1):155-8. doi: 10.1128/AAC.38.1.155.
The susceptibilities of 109 strains of Neisseria gonorrhoeae to penicillin G, tetracycline, amoxicillin-clavulanic acid, cefotetan, cefoxitin, ceftriaxone, ciprofloxacin, and fleroxacin were determined. The activities of cefmetazole, cefuroxime, cefixime, and ofloxacin were also determined against 62 of these strains. Strains represented penicillin-susceptible (Pen(s)) N. gonorrhoeae; penicillinase-producing N. gonorrhoeae (PPNG) possessing 2.9-, 3.05-, 3.2-, or 4.4-MDa beta-lactamase plasmids; strains with high-level, plasmid-mediated tetracycline resistance (TRNG); strains with plasmid-mediated resistance to penicillin and tetracycline; and strains with chromosomally mediated resistance to penicillin and tetracycline (CMRNG). Ceftriaxone, cefixime, and ciprofloxacin were the most active agents tested against all strains. Pen(s), TRNG, and PPNG strains possessing a 3.2-MDa beta-lactamase plasmid were more susceptible to amoxicillin-clavulanic acid, extended- and broad-spectrum cephalosporins, and quinolones than were either PPNG strains possessing a 2.9-, a 3.05-, or a 4.4-MDa beta-lactamase plasmid or CMRNG strains.
测定了109株淋病奈瑟菌对青霉素G、四环素、阿莫西林-克拉维酸、头孢替坦、头孢西丁、头孢曲松、环丙沙星和氟罗沙星的敏感性。还针对其中62株菌株测定了头孢美唑、头孢呋辛、头孢克肟和氧氟沙星的活性。这些菌株代表了对青霉素敏感（Pen(s)）的淋病奈瑟菌；携带2.9、3.05、3.2或4.4兆达尔β-内酰胺酶质粒的产青霉素酶淋病奈瑟菌（PPNG）；具有高水平、质粒介导的四环素耐药性的菌株（TRNG）；对青霉素和四环素具有质粒介导耐药性的菌株；以及对青霉素和四环素具有染色体介导耐药性的菌株（CMRNG）。头孢曲松、头孢克肟和环丙沙星是针对所有菌株测试中活性最强的药物。与携带2.9、3.05或4.4兆达尔β-内酰胺酶质粒的PPNG菌株或CMRNG菌株相比，携带3.2兆达尔β-内酰胺酶质粒的Pen(s)、TRNG和PPNG菌株对阿莫西林-克拉维酸、广谱和超广谱头孢菌素以及喹诺酮类药物更敏感。
