Bowerman B
Institute of Molecular Biology, University of Oregon, Eugene 97403, USA.
Bioessays. 1995 May;17(5):405-14. doi: 10.1002/bies.950170508.
Genetic and molecular studies of development in Caenorhabditis elegans have identified regulators that appear to control pattern formation in the cellularized nematode embryo. Two genes, skn-1 and pie-1, are required for specifying the different identities of two sister blastomeres in a 4-cell embryo, called P2 and EMS. The skn-1 gene encodes a DNA binding protein that may control blastomere development by regulating transcription in EMS and its descendants. ABa and ABp, the other two sisters in a 4-cell embryo, are influenced to develop differently by cell signaling events that require the two genes apx-1 and glp-1. In this review, I summarize evidence that some or all of these genes may encode embryonic determinants of blastomere identity.
秀丽隐杆线虫发育的遗传学和分子学研究已经鉴定出一些调控因子，这些调控因子似乎控制着细胞化线虫胚胎中的模式形成。有两个基因，skn-1和pie-1，对于确定四细胞胚胎中两个姐妹卵裂球（称为P2和EMS）的不同特性是必需的。skn-1基因编码一种DNA结合蛋白，它可能通过调节EMS及其后代中的转录来控制卵裂球的发育。四细胞胚胎中的另外两个姐妹ABa和ABp，受到需要apx-1和glp-1这两个基因的细胞信号事件的影响而有不同的发育。在这篇综述中，我总结了一些证据，表明这些基因中的一些或全部可能编码卵裂球特性的胚胎决定因子。
