Chugh S N, Kamar P, Sharma A, Chugh K, Mittal A, Arora B
Department of Medicine, Biochemistry and Pathology, Medical College & Hospital, Rohtak, Haryana, India.
Magnes Res. 1994 Dec;7(3-4):289-94.
The results of an open randomized study on magnesium status and parenteral magnesium sulphate therapy in acute aluminium phosphide intoxication are presented. The study was conducted on 105 patients divided into two group (I & II). Patients of Group I did not receive parenteral magnesium and acted as blank. Magnesium levels were monitored every 6 h for 24 h. Patients of group II received magnesium sulphate therapy. It was administered as 1.0 g (8.1 mEq or 4.05 mmol) magnesium sulphate dissolved in 100 ml of 5 per cent dextrose intravenously as a bolus dose followed by 1.0 g every hour for three successive hours, then 1.0 g every 6 h as a maintenance dose for the next 24 h as intravenous infusion in 5 per cent dextrose. The total dose of magnesium sulphate infused was 30.0 mmol over a period of 24 h (initial dose), then 16.0 mmol (4.0 g) daily till final outcome or a maximum of five days. All the vital parameters were monitored. All the patients were followed till final outcome. The resuscitation methods used were the same in both groups. At the end of the study, mortality rates were calculated in both groups. Hypomagnesaemia was observed as the constant finding in patients of Group I. It was transient and reversed itself without MgSO4. The mortality rate was 52 per cent. On the other hand, magnesium levels rose immediately after parenteral MgSO4 administration in patients of group II and they remained persistently above normal during the observed period.(ABSTRACT TRUNCATED AT 250 WORDS)
本文介绍了一项关于急性磷化铝中毒患者镁状态及硫酸镁静脉治疗的开放性随机研究结果。该研究共纳入105例患者，分为两组（I组和II组）。I组患者未接受硫酸镁静脉治疗，作为空白对照。每6小时监测一次镁水平，共监测24小时。II组患者接受硫酸镁治疗，具体方案为：先将1.0 g（8.1 mEq或4.05 mmol）硫酸镁溶于100 ml 5%葡萄糖溶液中静脉推注，随后连续3小时每小时静脉输注1.0 g，之后每6小时静脉输注1.0 g作为维持剂量，持续24小时。24小时内硫酸镁的总输注量为30.0 mmol（初始剂量），之后每天输注16.0 mmol（4.0 g），直至观察结束或最长持续5天。监测所有生命体征参数。所有患者均随访至观察结束。两组采用相同的复苏方法。研究结束时，计算两组的死亡率。I组患者持续出现低镁血症，该情况短暂且未经硫酸镁治疗自行恢复，死亡率为52%。另一方面，II组患者静脉输注硫酸镁后镁水平立即升高，且在观察期内一直持续高于正常水平。（摘要截选至250字）
