纤毛摆动频率由动力蛋白轻链磷酸化控制。
Ciliary beat frequency is controlled by a dynein light chain phosphorylation.
作者信息
Satir P, Barkalow K, Hamasaki T
机构信息
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
Biophys J. 1995 Apr;68(4 Suppl):222S.
cAMP-dependent phosphorylation of a 29-kDa axonemal polypeptide (p29) increases the swimming speed of permeabilized Paramecium and in vitro translocation velocity of bovine brain microtubules over 22S dynein extracted from Paramecium axonemes. A quantitative relationship between microtubule translocation velocity and beat frequency is developed. We conclude that p29 acts as a regulatory light chain of outer arm dynein in the control of ciliary beat frequency.
一种29 kDa轴丝多肽（p29）的环磷酸腺苷（cAMP）依赖性磷酸化作用可提高通透的草履虫的游动速度以及牛脑微管相对于从草履虫轴丝中提取的22S动力蛋白的体外转运速度。由此建立了微管转运速度与搏动频率之间的定量关系。我们得出结论，p29在纤毛搏动频率的控制中作为外臂动力蛋白的调节轻链发挥作用。
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