Yeoh E, Horowitz M, Russo A, Muecke T, Robb T, Chatterton B
Department of Radiation Oncology, Royal Adelaide Hospital, Australia.
J Gastroenterol Hepatol. 1995 Mar-Apr;10(2):125-30. doi: 10.1111/j.1440-1746.1995.tb01065.x.
To evaluate the long-term effects of abdominal irradiation for the treatment of seminoma of the testis on gastrointestinal function, 15 randomly selected patients who had been treated for stage I seminoma of the testis 2-10 years previously had the following parameters of gastrointestinal function evaluated: gastrointestinal symptoms; absorption of bile acid; vitamin B12; lactose and fat; gastric emptying; small intestinal and total gut transit; and intestinal permeability. Results were compared to those obtained in 18 normal volunteers. There was an increased prevalence of gastrointestinal symptoms (P < 0.01) in the patients and stool frequency was above the control range in two of them. Gastric emptying was faster (P < 0.01) in the patients. There were no significant differences in vitamin B12, bile acid, lactose or fat absorption, small intestinal transit or whole gut transit between the two groups, although faecal fat excretion was greater than the control range in three of the patients. At least one parameter of gastrointestinal function was abnormal in 11 of the 15 patients. Patients with right-sided seminoma had a greater bowel frequency when compared to those with left-sided seminoma (P < 0.05). We conclude that mild abnormalities in gastrointestinal function occur frequently when abdominal irradiation is used to treat stage I seminoma.
为评估腹部放疗治疗睾丸精原细胞瘤对胃肠功能的长期影响，随机选取15例2至10年前接受过I期睾丸精原细胞瘤治疗的患者，对以下胃肠功能参数进行评估：胃肠道症状；胆汁酸、维生素B12、乳糖及脂肪的吸收；胃排空；小肠及全肠道转运；以及肠道通透性。将结果与18名正常志愿者的结果进行比较。患者胃肠道症状的发生率增加（P < 0.01），其中2例患者的排便频率超出对照范围。患者的胃排空更快（P < 0.01）。两组之间维生素B12、胆汁酸、乳糖或脂肪吸收、小肠转运或全肠道转运方面无显著差异，不过3例患者的粪便脂肪排泄量超出对照范围。15例患者中有11例至少有一项胃肠功能参数异常。右侧睾丸精原细胞瘤患者与左侧睾丸精原细胞瘤患者相比，排便频率更高（P < 0.05）。我们得出结论，采用腹部放疗治疗I期睾丸精原细胞瘤时，胃肠功能常出现轻度异常。
