Kuz'min O B, Tarasov S V
Eksp Klin Farmakol. 1995 Jan-Feb;58(1):37-40.
Strophanthin (0.1 mg.kg, i.v.) and digoxin (0.1 mg/kg, i.v.) moderately increase blood supply of the renal cortical and medullary layers in unconscious rats and enhance renal excretion of sodium and water. Preadministration of the converting enzyme inhibitor captopril (10 mg/kg/day, per os, for 6 days) promoted vascular dilatation in the inner and outer areas of the medulla, which occurred under the action of these agents and substantially increased their natriuretic and diuretic effects. It is concluded that the renin-angiotension system is directly involved into the mechanism of action of cardiac glycosides in the kidneys, acting as a modulator that prevents their vasodilating and tubular effects.
毒毛花苷（0.1毫克/千克，静脉注射）和地高辛（0.1毫克/千克，静脉注射）可适度增加麻醉大鼠肾皮质和髓质层的血液供应，并增强肾钠和水的排泄。预先给予转化酶抑制剂卡托普利（10毫克/千克/天，口服，共6天）可促进在这些药物作用下发生的髓质内外区域血管舒张，并显著增强其利钠和利尿作用。得出的结论是，肾素 - 血管紧张素系统直接参与强心苷在肾脏中的作用机制，作为一种调节剂，可防止其血管舒张和肾小管作用。
