Kuz'min O B, Tarasov S V
Eksp Klin Farmakol. 1992 Mar-Apr;55(2):30-2.
Strophanthine (0.1 mg/kg, i. v.) and digoxin (0.1 mg/kg, i. v.) increase blood supply of the cortex and medullary layer of the kidneys of anesthetized rats and significantly raise excretion of water and sodium by the kidneys. Verapamil, a blocker of Ca(2+)-channels (0.25 mg/kg, i. v.) attenuates the increment of the blood flow in the internal zone of the cortex and external zone of the medullary layer but does not prevent the rise of diuresis and excretion of sodium with urine under the action of the above-indicated drugs. The conclusion is drawn that realization of the vasodilatory effect of cardiac glycosides in the kidneys is partially connected with a lowering of the content of Ca2+ in myofibrils whereas formation of their tubular effect does not depend on the changes in Ca2+ concentration in nephron cells.
毒毛花苷（0.1毫克/千克，静脉注射）和地高辛（0.1毫克/千克，静脉注射）可增加麻醉大鼠肾脏皮质和髓质层的血液供应，并显著提高肾脏对水和钠的排泄。钙通道阻滞剂维拉帕米（0.25毫克/千克，静脉注射）可减弱皮质内区和髓质层外区血流的增加，但在上述药物作用下并不能阻止利尿和尿钠排泄的增加。得出的结论是，强心苷在肾脏中的血管舒张作用的实现部分与肌原纤维中Ca2+含量的降低有关，而其肾小管效应的形成并不依赖于肾单位细胞中Ca2+浓度的变化。
