Inamo Y, Pemberton S, Tuddenham E G, Woo P
Section of Molecular Rheumatology, Northwick Park Hospital, Harrow.
Br J Rheumatol. 1995 May;34(5):466-9. doi: 10.1093/rheumatology/34.5.466.
Activated factor VIIa (FVIIa), von Willebrand factor antigen (vWF:Ag), D-dimer and thrombin-antithrombin III complex (TAT) were measured to monitor coagulation status in patients with juvenile chronic arthritis (JCA). Subjects included 14 patients with systemic JCA, 16 with pauciarticular JCA and 16 with polyarticular JCA without disseminated intravascular coagulopathy, thrombosis or liver dysfunction. All types of JCA showed an increase of FVIIa, D-dimer and TAT, indicating enhanced activation of coagulation. In systemic JCA only there was also characteristically an elevation of vWF:Ag. We conclude that all types of JCA constitute a state of subclinical hypercoagulopathy caused by tissue damage and that additionally systemic JCA involves a prothrombotic state associated with or precipitated by vasculitis.
检测活化凝血因子VIIa（FVIIa）、血管性血友病因子抗原（vWF:Ag）、D - 二聚体和凝血酶 - 抗凝血酶III复合物（TAT），以监测青少年慢性关节炎（JCA）患者的凝血状态。研究对象包括14例全身型JCA患者、16例少关节型JCA患者和16例多关节型JCA患者，这些患者均无弥散性血管内凝血、血栓形成或肝功能障碍。所有类型的JCA均显示FVIIa、D - 二聚体和TAT升高，表明凝血激活增强。仅在全身型JCA中，vWF:Ag也有特征性升高。我们得出结论，所有类型的JCA均构成由组织损伤引起的亚临床高凝状态，此外，全身型JCA还涉及与血管炎相关或由血管炎引发的血栓前状态。
