Creagh T A, Gleeson M, Travis D, Grainger R, McDermott T E, Butler M R
Meath Hospital, Dublin, Ireland.
Br J Urol. 1995 Apr;75(4):477-9. doi: 10.1111/j.1464-410x.1995.tb07268.x.
To assess the role of in vivo staining with intravesical methylene blue in predicting tumour recurrence.
Thirty-nine patients (27 men and 12 women, age range 43-75 years) newly diagnosed with bladder tumours were prospectively studied and followed for a minimum of 2 years. Potential biopsy sites were identified by staining intravesically with a 1% methylene blue solution and compared with random biopsy sites.
Biopsy directed by methylene blue staining detected carcinoma in situ more often than random biopsy. Rates of recurrence were similar in both stained and unstained groups.
Methylene blue staining does not add significantly to the management of patients presenting with bladder tumours.
评估膀胱内注入亚甲蓝进行体内染色在预测肿瘤复发中的作用。
对39例新诊断为膀胱肿瘤的患者（27例男性和12例女性，年龄范围43 - 75岁）进行前瞻性研究，并至少随访2年。通过膀胱内注入1%亚甲蓝溶液来确定潜在的活检部位，并与随机活检部位进行比较。
亚甲蓝染色引导下的活检比随机活检更常检测到原位癌。染色组和未染色组的复发率相似。
亚甲蓝染色对膀胱肿瘤患者的治疗并无显著附加价值。
