The Nd:YAG laser and methylene blue staining in the diagnosis and treatment of premalignant vesical lesions and carcinoma in situ (CIS).

The aim of this report is to emphasize the use of methylene staining test and the Nd:YAG laser in the diagnosis and treatment of premalignant lesions and CIS of the bladder. The use of an appropriate solution of methylene blue (0.2% in 0.9 M NaCl for 15 min) permits the staining of premalignant areas and CIS, and their early diagnosis. Laser irradiation of the stained areas facilitates the treatment of lesions. The technique was utilized in 8 patients without noteworthy side effects. It allowed an adequate treatment of the lesions and provided good results.