Ames G F, Spurich E N
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1877-81. doi: 10.1073/pnas.73.6.1877.
A component of the high-affinity histidine transport system in Salmonella typhimurium, the periplasmic histidine-binding protein J, interacts with another transport component, the P protein. A mutant J protein, with a defective interaction site but intact histidine-binding site, can function in histidine transport if an appropriate compensating mutation is introduced in the P protein. The interaction between the J and P proteins is an obligatory step in transport. The significance of this interaction and of the involvement of the P protein in multiple transport functions is discussed.
鼠伤寒沙门氏菌中高亲和力组氨酸转运系统的一个组分，即周质组氨酸结合蛋白J，与另一个转运组分P蛋白相互作用。一种具有缺陷性相互作用位点但组氨酸结合位点完整的突变型J蛋白，如果在P蛋白中引入适当的补偿性突变，就能在组氨酸转运中发挥作用。J蛋白和P蛋白之间的相互作用是转运过程中的一个必要步骤。本文讨论了这种相互作用的意义以及P蛋白参与多种转运功能的情况。
