Cormican M G, Marshall S A, Jones R N
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA.
Diagn Microbiol Infect Dis. 1995 Jan;21(1):51-4. doi: 10.1016/0732-8893(94)00116-e.
Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80% of isolates resistant (minimum inhibitory concentration, > or = 4 micrograms/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.
目前对氟喹诺酮类药物不断出现的耐药性促使人们合成该类新化合物。我们已评估了新型卤代喹诺酮DU - 6859a相对于环丙沙星、克林沙星、氟罗沙星、左氧氟沙星、氧氟沙星和司帕沙星对一组300种细菌的活性。DU - 6859a是所研究的氟喹诺酮类药物中活性最强的，对80%对环丙沙星耐药（最低抑菌浓度≥4微克/毫升）的分离株仍具有潜在的有效活性。强烈建议对DU - 6859a及类似新喹诺酮类药物继续进行临床研究。
