DU-6859a与克林沙星（CI-960）对葡萄球菌的杀菌活性
Bactericidal activities of DU-6859a and clinafloxacin (CI-960) against staphylococci.
作者信息
Forstall G J, Knapp C C, Washington J A
机构信息
Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195-5140.
出版信息
Antimicrob Agents Chemother. 1994 Aug;38(8):1868-70. doi: 10.1128/AAC.38.8.1868.
Abstract
Time killing curves were calculated at concentrations of 2 and 8 times the MICs of DU-6859a and clinafloxacin against six isolates of Staphylococcus aureus. Both quinolones produced a decrease in the log10 CFU per milliliter of > or = 3 within 3 h at 2 and 8 times the MIC for the ciprofloxacin-susceptible isolates and at 8 times the MIC for the ciprofloxacin-resistant isolates; however, only 8 times the MIC of DU-6859a consistently prevented regrowth of all isolates after 24 h of incubation.
摘要
针对6株金黄色葡萄球菌，以DU - 6859a和克林沙星的最低抑菌浓度（MIC）的2倍和8倍浓度计算杀菌曲线。对于环丙沙星敏感菌株，在2倍和8倍MIC浓度下，以及对于环丙沙星耐药菌株在8倍MIC浓度下，两种喹诺酮类药物均能在3小时内使每毫升菌落形成单位（CFU）的对数下降≥3；然而，只有DU - 6859a的8倍MIC浓度能在孵育24小时后持续抑制所有菌株的再生长。
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