确定人类染色体带1p13上三个基因座CD2、NGFB和NRAS的基因顺序，并通过荧光原位杂交在亚带水平上对其定位进行细化。
Determination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation.
作者信息
Mitchell E L, Jones D, White G R, Varley J M, Santibanez Koref M F
机构信息
Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
出版信息
Cytogenet Cell Genet. 1995;70(3-4):183-5. doi: 10.1159/000134028.
The three loci NRAS, NGFB, and CD2 map to human chromosome band 1p13. Using fluorescence in situ hybridisation (FISH) to simultaneously DAPI-banded metaphase chromosomes, we have further refined the localisation of these three genes to specific subbands. NRAS localises to subband 1p13.2 and CD2 and NGFB to 1p13.1. Also, with the use of multicolour FISH, we have determined the order and orientation of the three loci in relation to the centromere. The order is cen-CD2-NGFB-NRAS.
NRAS、NGFB和CD2这三个基因座定位于人类染色体1p13带。通过荧光原位杂交（FISH）技术对经DAPI染色的中期染色体进行分析，我们进一步将这三个基因的定位精确到了特定的亚带。NRAS定位于1p13.2亚带，CD2和NGFB定位于1p13.1亚带。此外，利用多色FISH技术，我们确定了这三个基因座相对于着丝粒的顺序和方向。顺序为着丝粒-CD2-NGFB-NRAS。
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