Lewis M, Ramsay D S
Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick 08903-0019, USA.
Child Dev. 1995 Jun;66(3):657-70. doi: 10.1111/j.1467-8624.1995.tb00896.x.
Infant stress responses to a well-baby physical examination and inoculation were observed longitudinally at 2, 4, and 6 months of age. In general, there were cortisol increases over base to the procedures. Cortisol level and cortisol response decreased with age. These data indicate a developmental shift in adrenocortical functioning between 2 and 6 months of age. Further evidence for this shift was seen in the stability of individual responses between 4 and 6 months of age. Individual differences in both cortisol and behavioral responses showed the most stability between these 2 ages. Moreover, diurnal variation in baseline cortisol level was present only at 6 months of age. While a sizable minority of infants showed stress-related cortisol decreases to the procedures at a given age, there was no evidence for cross-age consistency in individual infants showing these cortisol decreases.
对2个月、4个月和6个月大的婴儿进行了纵向观察，以了解他们对健康婴儿体检和接种疫苗的应激反应。一般来说，与基础水平相比，这些检查程序会使皮质醇水平升高。皮质醇水平和皮质醇反应随年龄增长而降低。这些数据表明，2至6个月大的婴儿肾上腺皮质功能发生了发育性变化。在4至6个月大的婴儿个体反应稳定性中可以看到这种变化的进一步证据。皮质醇和行为反应的个体差异在这两个年龄段之间表现出最大的稳定性。此外，只有在6个月大时才出现基线皮质醇水平的昼夜变化。虽然有相当一部分婴儿在特定年龄对这些检查程序表现出与压力相关的皮质醇水平下降，但没有证据表明在表现出这些皮质醇水平下降的个体婴儿中存在跨年龄的一致性。
