Ramsay D S, Lewis M
Institute for the Study of Child Development, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick 08903-0019.
Child Dev. 1994 Oct;65(5):1491-502. doi: 10.1111/j.1467-8624.1994.tb00831.x.
Infant cortisol and behavioral responses to receiving 1 versus 2 inoculations on 1 pediatric office visit were observed at 2 and 6 months of age. Cortisol level (pre- plus postinoculation level) decreased with age, whereas cortisol response (post- minus preinoculation level) did not vary with age when the data were aggregated over infants showing a pre- to postinoculation cortisol increase and those showing a decrease. Nonetheless, for those infants who showed a cortisol increase, cortisol level and response decreased with age. Infants quieted faster at the older age. There was a moderate relation between quieting behavior and cortisol response, at least for infants who showed a pre- to postinoculation cortisol increase. These findings indicate a developmental trend for a decline over age in adrenocortical reactivity to inoculation for infants showing a cortisol release following the perturbation. Results were comparable whether infants received 1 or 2 inoculations.
在2个月和6个月大时，观察了婴儿在一次儿科门诊接受1针与2针接种时的皮质醇和行为反应。皮质醇水平（接种前加接种后水平）随年龄降低，而当汇总接种前至接种后皮质醇升高和降低的婴儿数据时，皮质醇反应（接种后减去接种前水平）不随年龄变化。尽管如此，对于那些皮质醇升高的婴儿，皮质醇水平和反应随年龄降低。年龄较大的婴儿安静得更快。安静行为与皮质醇反应之间存在适度关系，至少对于接种前至接种后皮质醇升高的婴儿是如此。这些发现表明，对于接种后出现皮质醇释放的婴儿，随着年龄增长，肾上腺皮质对接种的反应性呈下降的发育趋势。无论婴儿接受1针还是2针接种，结果都是可比的。
