Qiao B, Wu Q, Wu D
School of Stomatology, Beijing Medical University.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1995 Jan;30(1):21-2, 63-4.
Proliferating cell nuclear antigen (PCNA) was identified by immunohistochemistry in 52 cases. PCNA-positive cells had been detected in the basal cells of normal epithelium known to contain proliferating cells. PCNA scores of normal epithelium was 1 as "low", and carcinomas were 3 or 4 as "high". The PCNA scores of high-grade carcinoma was significantly higher than the low-grade carcinoma. The study shows that expression of PCNA correlated with carcinoma grade.
通过免疫组织化学法在52例病例中鉴定出增殖细胞核抗原（PCNA）。在已知含有增殖细胞的正常上皮基底细胞中检测到PCNA阳性细胞。正常上皮的PCNA评分为1，为“低”，而癌组织的评分为3或4，为“高”。高级别癌的PCNA评分显著高于低级别癌。该研究表明，PCNA的表达与癌组织分级相关。
