D'Hooghe T M, Bambra C S, Raeymaekers B M, De Jonge I, Hill J A, Koninckx P R
Department of Reproduction, Institute of Primate Research, Nairobi, Kenya.
Fertil Steril. 1995 Jul;64(1):172-8.
To test the hypothesis that immunosuppression increases the development and progression of endometriosis in baboons.
Experimental controlled study.
Institute of Primate Research, Nairobi, Kenya.
Thirty-two baboons (8 with normal pelvis, 10 with spontaneous endometriosis, and 14 with endometriosis induced by intraperitoneal seeding of menstrual endometrium).
Daily injection of 0.8 mg/kg IM methylprednisolone and 2 mg/kg azathioprine for 3 months in 16 baboons (4 with normal pelvis, 5 with spontaneous endometriosis, and 7 with induced endometriosis). No treatment was given to the remaining 16 primates.
The change in number and surface area (mm2) of endometriotic lesions was evaluated by laparoscopy in all baboons after 3 months, in 8 animals with induced endometriosis and in 9 primates with spontaneous disease after 7 and 12 months, respectively.
Immunosuppressed baboons with spontaneous endometriosis had a significantly higher number and larger surface area of endometriotic lesions than nontreated animals. However, immunosuppressed and nontreated primates with induced endometriosis were comparable with respect to both number and surface area of implants. A transient decrease in typical lesions was noted during immunosuppression. Immunosuppression did not cause the development of endometriosis in baboons with previously documented normal pelvis.
Immunosuppression may increase the progression of endometriosis in baboons with spontaneous disease.
验证免疫抑制会增加狒狒子宫内膜异位症的发生和发展这一假说。
实验对照研究。
肯尼亚内罗毕灵长类动物研究所。
32只狒狒（8只骨盆正常，10只患有自发性子宫内膜异位症，14只通过腹腔接种月经子宫内膜诱导产生子宫内膜异位症）。
16只狒狒（4只骨盆正常，5只患有自发性子宫内膜异位症，7只患有诱导性子宫内膜异位症）每日肌注0.8mg/kg甲泼尼龙和2mg/kg硫唑嘌呤，持续3个月。其余16只灵长类动物不给予治疗。
3个月后对所有狒狒进行腹腔镜检查，评估子宫内膜异位症病变数量和表面积（mm²）的变化；分别在7个月和12个月后，对8只诱导性子宫内膜异位症动物和9只自发性疾病灵长类动物进行评估。
患有自发性子宫内膜异位症的免疫抑制狒狒，其子宫内膜异位症病变数量和表面积显著高于未治疗动物。然而，患有诱导性子宫内膜异位症的免疫抑制和未治疗的灵长类动物在植入物数量和表面积方面相当。免疫抑制期间，典型病变出现短暂减少。免疫抑制并未导致先前骨盆记录正常的狒狒发生子宫内膜异位症。
免疫抑制可能会增加患有自发性疾病的狒狒子宫内膜异位症的进展。
