Achiron R, Weissman A, Lipitz S, Mashiach S, Goldman B
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Gynecol Obstet Invest. 1995;39(3):153-6. doi: 10.1159/000292399.
Our objective was to review the association between fetal pleural effusion (FPE) and fetal aneuploidy. We conducted a retrospective survey of pregnant women who presented to our ultrasonographic unit between 1990 and 1991, and in whom the diagnosis of FPE was reached. All fetuses had karyotype investigation and a complete ultrasonographic search for associated anomalies. Six cases of FPE were identified. Trisomy 21 was found in 2 (33%). The English literature was reviewed and an additional 147 cases with FPE were collected, among them 6 cases of trisomy 21 and 1 of monosomy 45X. In this accumulated series the risk of aneuploidy in a fetus with an incidental finding of FPE was 5.8% (9 of 153), thus warranting a karyotype study.
我们的目的是回顾胎儿胸腔积液（FPE）与胎儿非整倍体之间的关联。我们对1990年至1991年间前来我们超声科就诊且被诊断为FPE的孕妇进行了一项回顾性调查。所有胎儿均进行了核型检查，并对相关异常进行了全面的超声检查。共识别出6例FPE病例。其中2例（33%）发现21三体。我们查阅了英文文献，并收集了另外147例FPE病例，其中6例为21三体，1例为45X单体。在这个累积系列中，偶然发现FPE的胎儿发生非整倍体的风险为5.8%（153例中有9例），因此有必要进行核型研究。
