Wira C R, Rossoll R M
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA.
Immunology. 1995 Apr;84(4):505-8.
We report here that the stage of the reproductive cycle and the administration of physiological amounts of oestradiol to ovariectomized rats influences antigen presentation by macrophage/dendritic cells in the vagina. Antigen presentation is elevated when oestradiol levels in blood are low, and reduced just prior to ovulation. Of those hormones tested, only oestradiol lowered vaginal antigen presentation. When progesterone was given along with oestradiol, the inhibitory effect of oestradiol on vaginal antigen presentation was reversed. These studies demonstrate that the vagina is an inductive site and that antigen presentation is under hormonal control. Our results suggest that immunization studies designed to enhance mucosal immunity in the female reproductive tract should take into account the stage of the reproductive cycle when antigen is deposited.
我们在此报告，生殖周期的阶段以及向卵巢切除的大鼠给予生理剂量的雌二醇，会影响阴道中巨噬细胞/树突状细胞的抗原呈递。当血液中的雌二醇水平较低时，抗原呈递会升高，而在排卵前则会降低。在所测试的激素中，只有雌二醇会降低阴道抗原呈递。当孕酮与雌二醇一起给予时，雌二醇对阴道抗原呈递的抑制作用会被逆转。这些研究表明，阴道是一个诱导部位，并且抗原呈递受激素控制。我们的结果表明，旨在增强女性生殖道黏膜免疫的免疫研究应考虑抗原沉积时的生殖周期阶段。
