抗原呈递细胞在诱导辅助性T细胞以产生细胞毒性T淋巴细胞反应中的作用：抗原加工的证据。
Antigen-presenting cell function in induction of helper T cells for cytotoxic T-lymphocyte responses: evidence for antigen processing.
作者信息
Weinberger O, Herrmann S, Mescher M F, Benacerraf B, Burakoff S J
出版信息
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1796-9. doi: 10.1073/pnas.78.3.1796.
Abstract
We demonstrate that splenic adherent cells (SACs) play an active role in the presentation of H-2Kk antigen for an alloreactive cytotoxic T-lymphocyte (CTL) response. If antigen is incubated with SACs for 12 hr, they will provide maximal stimulation and present the antigen in the context of their Ia molecules. UV irradiation of these SACs, prior to the 12-hr incubation with H-2Kk antigen, abrogates this stimulatory capacity. Macrophage-bound antigen is not sufficient for stimulation of a response; a second signal is required as well, that, in our system, is provided by phorbol myristic acetate. The SACs are involved in the activation of helper T cells; however, they are not required for presentation of antigen to the precytotoxic T-lymphocyte, which requires two signals for activation, one provided by antigen and the other by a T-cell-derived helper factor.
摘要
我们证明，脾黏附细胞（SACs）在呈递H-2Kk抗原以引发同种异体反应性细胞毒性T淋巴细胞（CTL）应答中发挥积极作用。如果将抗原与SACs孵育12小时，它们将提供最大刺激，并在其Ia分子的背景下呈递抗原。在与H-2Kk抗原进行12小时孵育之前，对这些SACs进行紫外线照射会消除这种刺激能力。巨噬细胞结合的抗原不足以刺激应答；还需要第二个信号，在我们的系统中，该信号由佛波酯肉豆蔻酸酯提供。SACs参与辅助性T细胞的激活；然而，将抗原呈递给细胞毒性前体T淋巴细胞并不需要它们，细胞毒性前体T淋巴细胞的激活需要两个信号，一个由抗原提供，另一个由T细胞衍生的辅助因子提供。
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