γ干扰素和肿瘤坏死因子α预处理的HEp-2细胞中肺炎衣原体生长的抑制作用
Inhibition of Chlamydia pneumoniae growth in HEp-2 cells pretreated with gamma interferon and tumor necrosis factor alpha.
作者信息
Summersgill J T, Sahney N N, Gaydos C A, Quinn T C, Ramirez J A
机构信息
Division of Infectious Diseases, University of Louisville School of Medicine, Kentucky, USA.
出版信息
Infect Immun. 1995 Jul;63(7):2801-3. doi: 10.1128/iai.63.7.2801-2803.1995.
Abstract
An in vitro culture system was used to study the effects of increasing concentrations of human cytokines on the intracellular replication of Chlamydia pneumoniae. HEp-2 cell monolayers, pretreated for 24 h with 200 U of human recombinant gamma interferon (IFN-gamma) per ml restricted the intracellular replication of C. pneumoniae. Tumor necrosis factor alpha (TNF-alpha; 25 ng/ml) exhibited a synergistic effect with IFN-gamma by reducing the concentration of IFN-gamma necessary to restrict intracellular growth to 100 U/ml. The addition of 200 micrograms of tryptophan per ml significantly reversed the inhibitory effects of IFN-gamma and TNF-alpha, suggesting involvement of the indoleamine-2,3-dioxygenase pathway in the restriction process.
摘要
采用体外培养系统研究人细胞因子浓度增加对肺炎衣原体细胞内复制的影响。每毫升含200单位人重组γ干扰素（IFN-γ）预处理24小时的HEp-2细胞单层可限制肺炎衣原体的细胞内复制。肿瘤坏死因子α（TNF-α；25纳克/毫升）与IFN-γ表现出协同作用，将限制细胞内生长所需的IFN-γ浓度降至100单位/毫升。每毫升添加200微克色氨酸可显著逆转IFN-γ和TNF-α的抑制作用，提示吲哚胺-2,3-双加氧酶途径参与了限制过程。
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