Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Istanbul University, Institute of Oncology, Capa, Turkey.
Int J Radiat Oncol Biol Phys. 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2.
Undifferentiated carcinoma of the nasopharynx (UCNT) is a particular head and neck epidermoid lineage tumor related to the Epstein Barr Virus (EBV). It has geographically selective endemic epidemiologic features, without relation to external carcinogens. Its systemic agressiveness is the source of most disease-related demises, because radiotherapy achieves excellent local control and a significant percentage of cure in patients with exclusive locoregional disease. Difference in the staying systems currently in use, the recent changes in imaging and radiotherapy technology, and the lack of distinction between UCNT and squamous cell carcinoma (SCC) of the nasopharynx in Western literature reports make for some difficulty in therapeutic results evaluation when analyzing available literature. Its chemosensitivity is a relatively recent acknowledged fact, and its use in metastatic patients results in a high percentage of objective responses, many of long duration. Neoadjuvant cisplatin-based chemotherapy seems to be of benefit, but outstanding controversies in this regard will be soon answered through ongoing phase III trials. After a review of the current literature of all the above-mentioned aspects of this fascinating nosologic entity, our own experience, both in metastatic and locoregional disease patients is analyzed.
鼻咽未分化癌（UCNT）是一种与爱泼斯坦-巴尔病毒（EBV）相关的特殊头颈部表皮样谱系肿瘤。它具有地理选择性的地方流行流行病学特征，与外部致癌物无关。其全身侵袭性是大多数疾病相关死亡的根源，因为放射治疗能在单纯局部区域疾病患者中实现出色的局部控制和相当比例的治愈。由于目前使用的分期系统存在差异、成像和放射治疗技术的最新变化，以及西方文献报道中鼻咽未分化癌与鼻咽癌鳞状细胞癌（SCC）之间缺乏区分，在分析现有文献时，治疗结果评估存在一定困难。其化学敏感性是一个相对较新被认可的事实，在转移性患者中使用可导致较高比例的客观缓解，且许多缓解持续时间较长。基于顺铂的新辅助化疗似乎有益，但这方面的突出争议将通过正在进行的III期试验很快得到解答。在回顾了关于这个引人入胜的疾病实体上述所有方面的当前文献后，我们分析了自己在转移性和局部区域疾病患者中的经验。
