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鼻咽癌经咽鼓管蔓延累及外耳道:一例报告。

External auditory canal involvement by nasopharyngeal carcinoma via eustachian tube spread: A case report.

作者信息

Yoon Won Young, Massoud Tarik F

机构信息

School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Department of Radiology, Stanford University School of Medicine, Stanford, California, United States.

出版信息

Radiol Case Rep. 2024 Aug 7;19(10):4604-4609. doi: 10.1016/j.radcr.2024.07.077. eCollection 2024 Oct.

DOI:10.1016/j.radcr.2024.07.077
PMID:39220784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11362798/
Abstract

We present the imaging findings of a 44-year-old female patient who was diagnosed with nasopharyngeal carcinoma (NPC) extending from the nasopharynx to the external auditory canal (EAC) through the Eustachian tube (ET). The patient presented with a left neck submandibular lump on initial presentation that showed NPC upon fine needle aspiration, leading to chemoradiotherapy. Despite treatment, the patient experienced multiple relapses and later presented with aural symptoms, including left ear pain, foul-smelling drainage, and trismus on recurrence, and was subsequently diagnosed through biopsy. CT, MRI, and PET-CT scans revealed an extensive infiltrative nasopharyngeal mass extending into the left ET, involving the EAC. This rare case highlights the importance of considering the extension of NPC into the EAC as a potential etiology in patients who present with aural symptoms.

摘要

我们展示了一名44岁女性患者的影像学检查结果,该患者被诊断为鼻咽癌(NPC),肿瘤通过咽鼓管(ET)从鼻咽部延伸至外耳道(EAC)。患者初诊时表现为左侧颈部下颌下肿块,细针穿刺显示为鼻咽癌,随后接受了放化疗。尽管进行了治疗,患者仍多次复发,后来出现耳部症状,包括左耳疼痛、恶臭分泌物以及复发时的牙关紧闭,随后通过活检确诊。CT、MRI和PET-CT扫描显示,鼻咽部有广泛浸润性肿块延伸至左侧咽鼓管,累及外耳道。这个罕见病例凸显了在出现耳部症状的患者中,将鼻咽癌延伸至外耳道视为潜在病因的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/176ee85996eb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/36c0edcb3534/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/89ad52f0766f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/4177f7845418/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/49754e615930/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/176ee85996eb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/36c0edcb3534/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/89ad52f0766f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/4177f7845418/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/49754e615930/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4422/11362798/176ee85996eb/gr5.jpg

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本文引用的文献

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Isolated Sixth Nerve Palsy as a First Presentation of Nasopharyngeal Carcinoma: A Case Series.孤立性第六脑神经麻痹作为鼻咽癌的首发表现:病例系列
Int Med Case Rep J. 2021 Nov 23;14:801-808. doi: 10.2147/IMCRJ.S334476. eCollection 2021.
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1987年至2011年中国南方广东省四会市鼻咽癌发病率趋势:年龄-时期-队列分析
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Epidemiology of nasopharyngeal carcinoma.鼻咽癌的流行病学
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Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosis.鼻咽癌:诊断前的症状表现及持续时间。
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Uncommon otological manifestations of nasopharyngeal carcinoma.鼻咽癌罕见的耳科表现。
J Laryngol Otol. 1999 Jun;113(6):558-60. doi: 10.1017/s0022215100144470.
8
Magnetic resonance imaging of the eustachian tube in nasopharyngeal carcinoma: correlation of patterns of spread with middle ear effusion.鼻咽癌咽鼓管的磁共振成像:扩散模式与中耳积液的相关性
Am J Otol. 1999 Jan;20(1):69-73.
9
Middle ear recurrence in two patients with nasopharyngeal carcinoma.两名鼻咽癌患者的中耳复发
Otolaryngol Head Neck Surg. 1998 Feb;118(2):280-2. doi: 10.1016/S0194-5998(98)80032-6.
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Trismus in patients with malignant tumours in the head and neck.头颈部恶性肿瘤患者的牙关紧闭
J Laryngol Otol. 1993 Nov;107(11):1017-20. doi: 10.1017/s0022215100125149.