Bylsma F W, Rasmusson D X, Rebok G W, Keyl P M, Tune L, Brandt J
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287-7218, USA.
Int J Psychophysiol. 1995 Feb;19(1):33-40. doi: 10.1016/0167-8760(94)00060-r.
Visual fixation and saccadic eye movements were assessed in 31 mild to moderately demented patients with probable Alzheimer's disease (AD) and 31 age- and education-matched nondemented elderly control subjects. Seventeen AD and 17 matched control subjects were reassessed after a 9-month interval. On a fixation task, duration of fixation and number of intrusive saccades were not different between groups at baseline or follow-up. Both AD patients and control subjects showed more intrusive saccades at follow-up than at baseline. AD patients showed increased latency to initiation of saccades at baseline and on follow-up. Amplitude and velocity of saccades were not different between groups at any visit. Changes in measures of fixation, but no saccade measure, correlated with changes in MMSE scores over testing sessions. These data suggest that fixation is more sensitive than are saccades to the progession of AD.
对31例患有可能的阿尔茨海默病（AD）的轻度至中度痴呆患者以及31名年龄和教育程度相匹配的非痴呆老年对照受试者进行了视觉注视和眼球跳动评估。17例AD患者和17名匹配的对照受试者在9个月的间隔后重新进行了评估。在一项注视任务中，两组在基线或随访时的注视持续时间和侵入性眼球跳动次数没有差异。AD患者和对照受试者在随访时的侵入性眼球跳动都比基线时更多。AD患者在基线和随访时启动眼球跳动的潜伏期增加。两组在任何一次就诊时眼球跳动的幅度和速度都没有差异。在测试过程中，注视指标的变化（但不是眼球跳动指标）与简易精神状态检查表（MMSE）评分的变化相关。这些数据表明，注视比眼球跳动对AD的进展更敏感。
