Renick A M
South Med J. 1976 Jun;69(6):775-8, 804. doi: 10.1097/00007611-197606000-00036.
Two cases of necrosis of skin and subcutaneous tissues in patients taking oral anticoagulants are reported, and the English literature is reviewed. The mechanism of coumarin necrosis remains unknown. Most patients are women and the lesions are most common on the abdomen, buttocks, thighs, and breasts. Simple mastectomy is the usual treatment for a breast lesion. Although some cases have been reported in which the skin lesion has healed despite continued anticoagulant therapy, curtailing its use is recommended. Heparin has not been associated with skin necrosis, however, and may be desirable if continued anticoagulant treatment is necessary.
报告了两例服用口服抗凝剂患者出现皮肤和皮下组织坏死的病例，并对英文文献进行了综述。香豆素坏死的机制尚不清楚。大多数患者为女性，病变最常见于腹部、臀部、大腿和乳房。单纯乳房切除术是乳房病变的常用治疗方法。尽管有报道称，一些病例在继续抗凝治疗的情况下皮肤病变仍愈合，但建议减少抗凝剂的使用。然而，肝素与皮肤坏死无关，如果需要继续抗凝治疗，肝素可能是可取的。
