Essex D W, Wynn S S, Jin D K
Department of Internal Medicine, State University of New York, Health Science Center at Brooklyn, 11203, USA.
Am J Hematol. 1998 Mar;57(3):233-7. doi: 10.1002/(sici)1096-8652(199803)57:3<233::aid-ajh10>3.0.co;2-b.
Warfarin-induced skin necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced skin necrosis and review the literature on this rarely reported variant of warfarin-induced skin necrosis. The skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C.
华法林诱导的皮肤坏死是华法林或其他香豆素衍生物治疗罕见的并发症。当它发生时，通常在治疗开始后3至6天出现，几乎总是在第1天至第10天之间。我们报告一例迟发性（治疗开始后16天）华法林诱导的皮肤坏死病例，并回顾关于这种罕见报道的华法林诱导皮肤坏死变体的文献。我们患者的皮肤病变与蛋白C缺乏或对活化蛋白C的抵抗均无关。
