Moskowitz M J, Ryan T P, Paulsen K D, Mitchell S E
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Int J Hyperthermia. 1995 Mar-Apr;11(2):141-9. doi: 10.3109/02656739509022452.
We describe the use of electrical impedance tomography (EIT) for non-invasive thermal imaging in conjunction with a clinical treatment of a superficial scalp lesion utilizing a spiral microstrip antenna. This is our first reported use of EIT with a clinical hyperthermia treatment and perhaps the first world-wide. The thermal measurements recorded during treatment compare favourably with the images reconstructed from impedance data gathered during heating. A linear relation, measured in phantom material, between the change in temperature with the change in reconstructed impedance was assumed. The average discrepancy between the measured temperature changes with the temperatures reconstructed from the impedance changes was 1.4 degrees C, with the maximum being 8.9 degrees C. These preliminary data suggest that impedance changes can be measured during hyperthermia delivery and temperature estimates based on these observed changes are possible in the clinical setting. These findings also point to the complex, yet critical nature of the impedance versus temperature relationship for tissue in vivo. The reconstructed thermal images may provide complementary information about the overall thermal damage imposed during heating. Based on this initial clinical experience we feel that EIT has great potential as a viable clinical aid in imaging the temperature changes imposed during hyperthermia.
我们描述了利用螺旋微带天线将电阻抗断层成像（EIT）用于浅表头皮病变临床治疗中的非侵入性热成像。这是我们首次报道将EIT用于临床热疗，可能也是全球首例。治疗期间记录的热测量结果与加热期间收集的阻抗数据重建的图像相比效果良好。假定在模拟材料中测量到温度变化与重建阻抗变化之间存在线性关系。测量的温度变化与根据阻抗变化重建的温度之间的平均差异为1.4摄氏度，最大差异为8.9摄氏度。这些初步数据表明，在热疗过程中可以测量阻抗变化，并且在临床环境中基于这些观察到的变化进行温度估计是可行的。这些发现还指出了体内组织阻抗与温度关系的复杂性和关键性质。重建的热图像可能提供有关加热过程中整体热损伤的补充信息。基于这一初步临床经验，我们认为EIT作为一种可行的临床辅助手段，在热疗期间成像温度变化方面具有巨大潜力。
