Kessel D, Woodburn K, Gomer C J, Jagerovic N, Smith K M
Department of Pharmacology and Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA.
J Photochem Photobiol B. 1995 Apr;28(1):13-8. doi: 10.1016/1011-1344(94)07085-3.
Biophysical and photobiological properties of three derivatives of chlorin p6 were examined. These agents can be considered as lysyl analogs of the aspartyl chlorin NPe6. Lysyl chlorin p6 diester (LCP) and the triester analog (LCP2) were readily accumulated by murine leukemia L1210 cells, localized in lysosomes, and were relatively inefficient photosensitizing agents in vitro. In contrast, lysyl chlorin e6 imide (LCI) was poorly accumulated, concentrated in mitochondrial and plasma membranes, but was more efficacious. LCI was the most effective agent with regard to photosensitization of a murine tumor in vivo, but all three agents caused substantially more toxicity than was observed with NPe6.
研究了二氢卟吩p6三种衍生物的生物物理和光生物学特性。这些试剂可被视为天冬氨酰二氢卟吩NPe6的赖氨酰类似物。赖氨酰二氢卟吩p6二酯（LCP）和三酯类似物（LCP2）很容易被小鼠白血病L1210细胞摄取，定位于溶酶体中，并且在体外是相对低效的光敏剂。相比之下，赖氨酰二氢卟吩e6酰亚胺（LCI）摄取较差，集中在线粒体和质膜中，但更有效。就体内小鼠肿瘤的光致敏而言，LCI是最有效的试剂，但所有三种试剂所引起的毒性都比NPe6观察到的要大得多。
