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皮肤利什曼病中的循环抗体:通过免疫荧光法进行检测

Circulating antibodies in cutaneous leishmaniasis: their detection by immunofluorescence.

作者信息

Matossian R M, Kurban A K, Malak J A

出版信息

Trans R Soc Trop Med Hyg. 1975;69(5-6):450-2. doi: 10.1016/0035-9203(75)90096-6.

Abstract

With the use of an indirect fluorescent antibody (IFA) test and freeze-dried antigens, circulating antibody titres of 1 in 100 or above to Leishmania tropica leptomonad forms were detected in 66-6% and 76-2% of 18 patients with active and 21 patients with healed cutaneous leishmaniasis, respectively. Cross-reactivity was observed with L. donovani and Trypanosoma cruzi antigens. Five out of 15 patients with active pulmonary tuberculosis had antibodies to L. tropica major, suggesting a possible cross-reactivity between the two agents.

摘要

使用间接荧光抗体(IFA)试验和冻干抗原,分别在18例活动性皮肤利什曼病患者中的66.6%以及21例已治愈皮肤利什曼病患者中的76.2%检测到针对热带利什曼原虫前鞭毛体形式的循环抗体效价为1:100或更高。观察到与杜氏利什曼原虫和克氏锥虫抗原存在交叉反应。15例活动性肺结核患者中有5例具有针对硕大利什曼原虫的抗体,提示这两种病原体之间可能存在交叉反应。

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