血清甲胎蛋白和人绒毛膜促性腺激素放射免疫测定在转移性睾丸肿瘤强化化疗及手术中的作用

The role of the radioimmunoassay of serum alpha-fetoprotein and human chorionic gonadotropin in the intensive chemotherapy and surgery of metastatic testicular tumors.

作者信息

Javadpour N, McIntire K R, Waldmann T A, Scardino P T, Bergman S, Anderson T

出版信息

J Urol. 1978 Jun;119(6):759-62. doi: 10.1016/s0022-5347(17)57625-9.

Abstract

Quantitative measurement of serum alpha-fetoprotein and human chorionic gonadotropin by double antibody radioimmunoassays reflects the efficacy of surgical, radiation and/or chemotherapeutic regimens in patients with bulky disseminated testicular tumors. When these therapies are effective they produce an immediate decrease in serum levels of these markers that reflects the decrease in tumor size and could be as rapid as the catabolic decay rate for alpha-fetoprotein or human chorionic gonadotropin. The alpha subunit of human chorionic gonadotropin has a short half-life (20 minutes) and has been used for the first time to localize a recurrent metastatic testicular tumor. Cellular localization of these markers by immunochemical techniques has helped us to understand the natural history of this cancer and the cell types responsible for production of the markers.

摘要

通过双抗体放射免疫测定法对血清甲胎蛋白和人绒毛膜促性腺激素进行定量测量，可反映出手术、放疗和/或化疗方案对患有大块播散性睾丸肿瘤患者的疗效。当这些治疗有效时，它们会使这些标志物的血清水平立即下降，这反映出肿瘤大小的减小，且下降速度可能与甲胎蛋白或人绒毛膜促性腺激素的分解代谢衰减率一样快。人绒毛膜促性腺激素的α亚基半衰期较短（20分钟），并且首次被用于定位复发性转移性睾丸肿瘤。通过免疫化学技术对这些标志物进行细胞定位，有助于我们了解这种癌症的自然病程以及产生这些标志物的细胞类型。