Murphy S M, Hegarty D M, Feighery C S, Walsh J B, Williams Y, Coakley D P
Mercer's Institute for Research on Ageing.
Age Ageing. 1995 Mar;24(2):99-102. doi: 10.1093/ageing/24.2.99.
The aims of this study were to document the level of tetanus immunity in elderly people; to assess the value of immunization history in predicting tetanus immune status and to determine the response to tetanus immunization in elderly people compared with younger subjects. One-hundred day-hospital attenders (group 1), 100 long-term-care residents (group 2) and 50 young subjects (group 3) were recruited. Protective titres of tetanus antitoxin antibodies were detected in 20% of group 1, 45% of group 2 and 80% of group 3. Tetanus immunization history was a poor predictor of immune status in older people with a positive predictive value of 50% and a negative predictive value of 76%. The response to tetanus immunization was slower and of lower magnitude in older people. However, 36 of 37 older subjects developed protective levels of tetanus antitoxin antibodies on completion of a primary immunization programme.
本研究的目的是记录老年人破伤风免疫水平；评估免疫史在预测破伤风免疫状态方面的价值，并确定老年人与年轻受试者相比对破伤风免疫接种的反应。招募了100名日间医院就诊者（第1组）、100名长期护理居民（第2组）和50名年轻受试者（第3组）。第1组20%、第2组45%和第3组80%检测到破伤风抗毒素抗体的保护性滴度。破伤风免疫史对老年人免疫状态的预测能力较差，阳性预测值为50%，阴性预测值为76%。老年人对破伤风免疫接种的反应较慢且程度较低。然而，37名老年受试者中有36名在完成初次免疫程序后产生了破伤风抗毒素抗体的保护水平。
