土耳其博卢养老院居民的破伤风免疫力

Tetanus immunity in nursing home residents of Bolu, Turkey.

作者信息

Karabay Oguz, Ozkardes Fatma, Tamer Ali, Karaarslan Kazim

机构信息

Department of Infectious Diseases and Clinical Microbiology, Izzet Baysal University, Faculty of Medicine, Golkoy, Bolu, Turkey.

出版信息

BMC Public Health. 2005 Jan 12;5:5. doi: 10.1186/1471-2458-5-5.

DOI:10.1186/1471-2458-5-5

PMID:15647120

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC545067/

Abstract

BACKGROUND

Tetanus is a serious but vaccine-preventable disease and fatality rate of the disease is high in the neonates and the elderly. The aim of this study was to detect the tetanus antibody prevalence in the over sixty-year age residents of the nursing homes in Bolu.

METHODS

A voluntary-based study was done in the residents of two nursing homes in Bolu, Turkey. Blood samples were taken from 71 volunteers residing in there nursing homes. Tetanus IgG antibodies were measured by a commercial ELISA kit.

RESULTS

Among overall subjects, only 11 (15.7 %) had the protective tetanus antibody titers at the time of the study. Totally, 10 subjects were examined in emergency rooms due to trauma or accidents within the last ten years and, four (40%) of them had protective antibody levels. Of the remaining 61 subjects only 7 (11%) had protective antibody levels (p < 0.05) [Relative Risk = 3.49, 95% Confidence Interval 1.24-9.77].

CONCLUSIONS

Tetanus antibody level is below the protective level in the majority of the over-sixty-year-age subjects residing in the nursing homes. Each over sixty-year age person in our country should be vaccinated. Until this is accomplished, at least, nursing home residents should be vaccinated during registration.

摘要

背景

破伤风是一种严重但可通过疫苗预防的疾病，在新生儿和老年人中该疾病的死亡率很高。本研究的目的是检测博卢养老院60岁以上居民中破伤风抗体的流行情况。

方法

在土耳其博卢的两家养老院的居民中开展了一项基于自愿参与的研究。从居住在这两家养老院的71名志愿者身上采集血样。使用商用ELISA试剂盒检测破伤风IgG抗体。

结果

在所有受试者中，研究时只有11人（15.7%）具有保护性破伤风抗体滴度。在过去十年中，共有10名受试者因创伤或事故在急诊室接受检查，其中4人（40%）具有保护性抗体水平。在其余61名受试者中，只有7人（11%）具有保护性抗体水平（p<0.05）[相对风险=3.49，95%置信区间1.24 - 9.77]。