Cavenagh E C, Weinberger E, Shaw D W, White K S, Geyer J R
Department of Radiology, University of Washington School of Medicine, Seattle, USA.
AJNR Am J Neuroradiol. 1995 Mar;16(3):461-7.
To evaluate changes in vertebral marrow signal intensity that occur over time in children undergoing craniospinal radiation therapy, specifically evaluating for the occurrence and timing of marrow regeneration.
MR images of nine pediatric patients (ages 4 to 12 years) with posterior fossa medulloblastoma who received total spinal irradiation (24 to 40 Gy) and had at least three MR examinations were reviewed. Signal intensity to vertebral body marrow was graded by two pediatric neuroradiologists who were blinded to patient identity and to the timing of the studies.
Eight of nine patients demonstrated increasing signal intensity of the vertebral marrow after irradiation, consistent with conversion of hematopoietic to fatty marrow. In each of these patients, this was followed by subsequent decreasing signal intensity in a mottled or peripheral band pattern indicating recovery of hematopoietic marrow.
Changes in vertebral body signal intensity consistent with marrow reconversion commonly are seen in pediatric patients 11 to 30 months after they undergo total spinal irradiation.
评估接受颅脊髓放射治疗的儿童随时间推移椎骨髓信号强度的变化，特别评估骨髓再生的发生情况和时间。
回顾了9例患有后颅窝髓母细胞瘤的儿科患者（年龄4至12岁）的磁共振成像（MR），这些患者接受了全脊髓照射（24至40 Gy）且至少进行了三次MR检查。两名儿科神经放射科医生对椎体骨髓的信号强度进行分级，他们对患者身份和研究时间不知情。
9例患者中有8例在照射后显示椎骨髓信号强度增加，这与造血骨髓向脂肪骨髓的转变一致。在这些患者中的每一例中，随后均出现信号强度以斑驳或外周带状模式降低，表明造血骨髓恢复。
在儿科患者接受全脊髓照射后11至30个月，常可见到与骨髓再转化一致的椎体信号强度变化。
