Roman-Goldstein S, Mitchell P, Crossen J R, Williams P C, Tindall A, Neuwelt E A
Department of Diagnostic Radiology, Oregon Health Sciences University, Portland 97201-3098, USA.
AJNR Am J Neuroradiol. 1995 Mar;16(3):543-53.
To determine whether osmotic blood-brain barrier disruption is associated with MR abnormalities or cognitive deterioration and, if so, whether the MR findings correlate with cognitive test results.
Fifteen brain tumor patients who had a complete tumor response (nine central nervous system lymphoma, three germ cell and two astrocytoma, and one primitive neuroectodermal tumor) treated with blood-brain barrier disruption procedures (318 total procedures) with intraarterial chemotherapy were included. MR images were evaluated for the development of white matter hyperintensity, vascular lesions, or atrophy. Cognitive testing was performed to assess deterioration caused by this therapy.
In two patients white matter hyperintensity developed, in two small vascular lesions developed, and in one mild atrophy developed. One infarct was asymptomatic and the second one resulted in mild dysesthesia in one upper extremity. No patient showed diminished cognitive function on the posttherapy evaluation.
In patients undergoing blood-brain barrier disruption with intraarterial chemotherapy, new abnormalities on MR imaging may develop. These patients maintain the same level of cognitive and neurologic function and MR findings do not correlate with the results of cognitive testing.
确定渗透性血脑屏障破坏是否与磁共振成像（MR）异常或认知功能减退相关，若相关，MR表现是否与认知测试结果相关。
纳入15例接受血脑屏障破坏程序（共318次程序）联合动脉内化疗且肿瘤完全缓解的脑肿瘤患者（9例中枢神经系统淋巴瘤、3例生殖细胞瘤、2例星形细胞瘤和1例原始神经外胚层肿瘤）。评估MR图像上白质高信号、血管病变或萎缩的发生情况。进行认知测试以评估该治疗引起的功能减退。
2例出现白质高信号，2例出现小血管病变，1例出现轻度萎缩。1例梗死无症状，第2例导致一侧上肢轻度感觉异常。治疗后评估中无患者出现认知功能减退。
在接受动脉内化疗联合血脑屏障破坏的患者中，MR成像可能会出现新的异常。这些患者的认知和神经功能维持在相同水平，且MR表现与认知测试结果不相关。
