Kumar P, Jagetia G C
Department of Plastic Surgery, Kasturba Hospital, Manipal, India.
Burns. 1995 May;21(3):163-5. doi: 10.1016/0305-4179(95)80001-5.
Changes in wound healing were studied using artificial wounds created either by surgical excision of full thickness skin or partial skin thickness dermabrasion of dorsal skin of Swiss albino mice exposed to 2, 4 and 6 Gy of gamma radiation. There was a significant delay in the wound healing process after exposure to 2 Gy when compared to the controls. With increasing doses of radiation wound healing time was also delayed. However, the differences in wound healing times between all three doses were not significant. The irradiation resulted in a dose-dependent delay in the wound contraction and mean wound healing time. The abrasion group was followed until complete epithelialization in the animals exposed to 2, 4 and 6 Gy of gamma radiation. However, no significant difference was observed in the healing time with respect to non-irradiated controls for all the exposure doses used in the present study.
利用通过手术切除全层皮肤或对暴露于2、4和6 Gy伽马辐射的瑞士白化小鼠背部皮肤进行部分皮肤厚度磨皮所造成的人工伤口，研究伤口愈合的变化。与对照组相比，暴露于2 Gy后伤口愈合过程出现显著延迟。随着辐射剂量增加，伤口愈合时间也延迟。然而，所有三个剂量之间的伤口愈合时间差异不显著。辐射导致伤口收缩和平均伤口愈合时间出现剂量依赖性延迟。对暴露于2、4和6 Gy伽马辐射的动物的磨皮组进行跟踪观察，直至完全上皮化。然而，在本研究中使用的所有暴露剂量下，与未辐照的对照组相比，愈合时间未观察到显著差异。
