Ranjbar Reza, Yousefi Alireza
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Bull Emerg Trauma. 2018 Jan;6(1):8-15. doi: 10.29252/beat-060102.
To assess effect of Aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria.
Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9% saline solution. Group II: Animals with infected wounds treated with saline. Group III: Animals with infected wounds were dressed with chitosan nanoparticle thin-film membranes. Group IV: Animals with infected wounds were treated topically with Aloe vera and Group V: Animals with infected wounds were treated topically with Aloe vera and dressed with chitosan nanoparticle thin-film membranes. Wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery.
Microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference (<0.05) between group V and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (<0.05) between group V and other groups.
The Aloe vera with chitosan nanoparticle thin-film membranes had a reproducible wound healing potential and hereby justified its use in practice.
评估含有壳聚糖纳米颗粒生物膜的芦荟对感染耐抗生素革兰氏阳性菌的全层伤口愈合的影响。
将30只大鼠随机分为五组，每组6只。第一组：用0.9%盐溶液处理未感染伤口的动物。第二组：用盐水处理感染伤口的动物。第三组：用壳聚糖纳米颗粒薄膜敷料处理感染伤口的动物。第四组：用芦荟局部处理感染伤口的动物，第五组：用芦荟局部处理感染伤口并用壳聚糖纳米颗粒薄膜敷料处理的动物。在术后6、9、12、15、18和21天测量伤口大小。
微生物学、伤口面积缩小和羟脯氨酸含量表明，第五组与其他组之间存在显著差异（<0.05）。定量组织学研究和定性研究的平均秩次表明，第五组与其他组之间存在显著差异（<0.05）。
含有壳聚糖纳米颗粒薄膜的芦荟具有可重复的伤口愈合潜力，因此证明了其在实践中的应用价值。
