Jagetia G C, Rajanikant G K
Department of Radiobiology, Kasturba Medical College, Manipal, India.
J Wound Care. 2004 Mar;13(3):107-9. doi: 10.12968/jowc.2004.13.3.26589.
To study the effect on wound contraction of pretreatment with various doses of curcumin (the most important active ingredient of the spice turmeric) in mice exposed to 6 Gy whole-body gamma radiation.
A full-thickness skin wound was produced on the dorsum of Swiss albino mice treated with and without 25, 50, 100, 150 or 200 mg/kg body weight of curcumin before exposure to 6 Gy gamma radiation. Progression of wound contraction was monitored using video images of the wound at various days post-irradiation until full healing occurred. Mean wound healing times were also calculated.
Irradiation caused significant delay in wound contraction and healing times. However, treatment with curcumin resulted in a dose-dependent increase in contraction when compared with a control. Greatest contraction was observed for 100 mg/kg curcumin, with statistically significant results at days three (p < 0.009), six (p < 0.05) and nine (p < 0.05) post-irradiation for this dose. Complete healing was achieved by day 23 post-irradiation in the curcumin-treated irradiation group.
Pretreatment with curcumin has a conductive effect on irradiated wounds. It could be a substantial therapeutic agent for ameliorating radiation-induced delay in wound repair in cases of combined injuries.
研究不同剂量姜黄素（香料姜黄中最重要的活性成分）预处理对接受6 Gy全身γ辐射小鼠伤口收缩的影响。
在瑞士白化小鼠背部制作全层皮肤伤口，将小鼠分为两组，一组在接受6 Gy γ辐射前分别给予25、50、100、150或200 mg/kg体重的姜黄素，另一组不给予姜黄素。在辐射后不同天数，使用伤口的视频图像监测伤口收缩进程，直至完全愈合。同时计算平均伤口愈合时间。
辐射导致伤口收缩和愈合时间显著延迟。然而，与对照组相比，姜黄素治疗导致收缩呈剂量依赖性增加。对于100 mg/kg姜黄素，观察到最大收缩，该剂量在辐射后第3天（p < 0.009）、第6天（p < 0.05）和第9天（p < 0.05）具有统计学显著结果。在姜黄素治疗的辐射组中，辐射后第23天实现完全愈合。
姜黄素预处理对辐射伤口有促进作用。在复合伤情况下，它可能是改善辐射诱导的伤口修复延迟的重要治疗剂。
