Johnson J A, Akers W S, Miller S T, Applegate W B
Department of Clinical Pharmacy, College of Pharmacy, University of Memphis 38163, USA.
Am J Hypertens. 1995 Mar;8(3):254-9. doi: 10.1016/0895-7061(94)00209-T.
Twelve hypertensive black males completed the study, which was conducted to evaluate the effect of metoprolol on 24-h ambulatory blood pressure (ABP). Study participants took 50 mg to 100 mg metoprolol twice daily for a minimum of 3 weeks. Metoprolol had no significant effect on blood pressure (147/90 +/- 11/8 mm Hg v 151/88 +/- 16/8 mm Hg, baseline v treated, respectively) in spite of causing significant reductions in heart rate (87 +/- 9 beats/min v 69 +/- 7 beats/min, P < .001). Only one subject had a > or = 10 mm Hg decrease in 24-h diastolic blood pressure. The nighttime fall in blood pressure was minimized by metoprolol and clinically significant increases in daytime or nighttime blood pressure were noted in 58% of patients. Metoprolol therapy failed to lower blood pressure and eliminated the normal nighttime decline in blood pressure. Since the nighttime decline in blood pressure is thought to protect against target organ damage, it may be important to identify antihypertensive agents which preserve or enhance the nighttime blood pressure dip.
12名高血压黑人男性完成了该研究，该研究旨在评估美托洛尔对24小时动态血压（ABP）的影响。研究参与者每天两次服用50毫克至100毫克美托洛尔，持续至少3周。尽管美托洛尔使心率显著降低（分别为87±9次/分钟对69±7次/分钟，P<.001），但对血压无显著影响（基线时为147/90±11/8毫米汞柱，治疗后为151/88±16/8毫米汞柱）。只有一名受试者24小时舒张压下降≥10毫米汞柱。美托洛尔使夜间血压下降最小化，58%的患者出现白天或夜间血压临床上显著升高。美托洛尔治疗未能降低血压，且消除了正常的夜间血压下降。由于夜间血压下降被认为可预防靶器官损害，因此识别能维持或增强夜间血压下降的抗高血压药物可能很重要。
