Howe D T, Wheeler T, Osmond C
Department of Obstetrics and Gynaecology, Princess Anne Hospital, Southampton, UK.
Br J Obstet Gynaecol. 1995 Mar;102(3):213-9. doi: 10.1111/j.1471-0528.1995.tb09096.x.
To investigate whether low maternal haemoglobin and ferritin levels are associated with increased placental volume by mid-pregnancy.
Prospective study of women attending hospital for shared antenatal care.
A teaching hospital in the south of England.
Five hundred and sixty-eight women booking for delivery in the hospital.
Placental volume measured by ultrasound at 18 weeks gestation.
At 14 weeks gestation 9% of women had haemoglobin levels < or = 11 g/dl and 26% had ferritin levels < 13 micrograms/l. Placental volume at 18 weeks was inversely related to the maternal haemoglobin and ferritin levels. The influence of haemoglobin and ferritin concentrations was independent of maternal social class, parity, smoking, and weight. Larger placentae were found in taller women, those who had previously been pregnant, and in those who were smoking more than 15 cigarettes daily at the time of their last menstrual period.
These data suggest that placental development is influenced from early in pregnancy by the intrauterine environment provided by the mother. In conjunction with other studies they support the proposal that, as a result of these changes, programming of adult blood pressure may be initiated in early pregnancy.
研究孕期中期孕妇血红蛋白和铁蛋白水平低是否与胎盘体积增大有关。
对参加共享产前护理的孕妇进行前瞻性研究。
英格兰南部的一家教学医院。
568名在该医院预约分娩的女性。
妊娠18周时通过超声测量胎盘体积。
妊娠14周时，9%的女性血红蛋白水平≤11 g/dl，26%的女性铁蛋白水平<13微克/升。妊娠18周时胎盘体积与孕妇血红蛋白和铁蛋白水平呈负相关。血红蛋白和铁蛋白浓度的影响独立于孕妇的社会阶层、产次、吸烟情况和体重。胎盘较大的女性身材较高、有过怀孕史，且在末次月经时每天吸烟超过15支。
这些数据表明，胎盘发育在妊娠早期就受到母亲提供的宫内环境的影响。与其他研究一起，它们支持了这样的观点，即由于这些变化，成人血压的编程可能在妊娠早期就开始了。
