Gutzmann F, Layton H, Simkins K, Jarolmen H
Am J Vet Res. 1976 Jun;37(6):649-55.
The effect of chlortetracycline given at a concentration of 220.5 g/metric ton of feed and of a combination product which supplies chlortetracycline (110.2 g/metric ton), sulfamethazine (110.2 g/metric ton), and penicilin G (55.1 g/metric ton) on the occurrence and persistence of Salmonella typhimurium in experimentally infected swine was studied. Weanling pigs (av weight, 8.2 kg) were inoculated via the feed with 10(11) colony-forming units of S typhimurium 298-1NA. An equal number of nonexposed swine given identical treatment were used as controls. Infected pigs had increased temperatures (maximal av, 41 C) for the first 4 days after infection and severe diarrhea during the first 21 days. The use of chlortetracycline and a combination product at subtherapeutic concentrations in feed did not increase the Salmonella pool or prolong the carrier state in swine. A decrease in number of Salmonella shed from swine given chlortetracycline at the concentration of 220.5 g/metric ton was observed. Significant differences did not occur in Salmonella-related deaths or in emergence of multiple antibiotic-resistant Salmonella by antibiotic selection or R factor transfer. Zoonotic transmission of the infecting Salmonella to animal caretakers was not detected.
研究了以220.5克/公吨饲料的浓度添加金霉素以及一种提供金霉素（110.2克/公吨）、磺胺二甲嘧啶（110.2克/公吨）和青霉素G（55.1克/公吨）的复合产品对实验感染猪中鼠伤寒沙门氏菌的发生和持续存在的影响。断奶仔猪（平均体重8.2千克）通过饲料接种10(11)个鼠伤寒沙门氏菌298 - 1NA菌落形成单位。将同等数量接受相同处理的未接触猪作为对照。感染猪在感染后的前4天体温升高（最高平均体温41℃），并且在前21天出现严重腹泻。在饲料中以亚治疗浓度使用金霉素和复合产品并没有增加猪体内沙门氏菌库或延长猪的带菌状态。观察到以220.5克/公吨浓度添加金霉素的猪排出的沙门氏菌数量减少。在与沙门氏菌相关的死亡情况以及通过抗生素选择或R因子转移出现多重耐药性沙门氏菌方面未出现显著差异。未检测到感染性沙门氏菌向动物饲养员的人畜共患病传播。
