Rummelt V, Folberg R, Rummelt C, Palay D A, Mathers W D, Parys-van Ginderdeuren R, Krachmer J H, Yi H
Department of Ophthalmology, University of Iowa, Iowa City 52242-1182, USA.
Ger J Ophthalmol. 1995 Mar;4(2):116-22.
This report describes the clinical, histopathologic, ultrastructural, and immunohistochemical findings in two corneal buttons from a 13-year-old girl who developed bilateral progressive corneal stromal opacification during childhood. As determined by light microscopy, both corneal buttons were edematous with a chronic inflammatory infiltrate confined to the deep layers of the stroma. We detected intranuclear eosinophilic inclusions in some epithelial cells. We detected herpesvirus particles in stromal keratocytes and endothelial cells by transmission electron microscopy. Immunohistochemistry studies identified concurrent expression of specific herpes simplex virus type 2 antigen in corneal epithelial cells, in keratocytes in the deep layers of the stroma, and in endothelial cells. The cause of progressive bilateral stromal corneal opacification in this child was herpes simplex virus type 2 keratitis. This condition should be considered in the differential diagnosis of progressive, bilateral corneal opacification in children.
本报告描述了一名13岁女孩的两枚角膜植片的临床、组织病理学、超微结构和免疫组化结果。该女孩在儿童期出现双侧进行性角膜基质混浊。通过光学显微镜检查确定，两枚角膜植片均有水肿，慢性炎症浸润局限于基质深层。我们在一些上皮细胞中检测到核内嗜酸性包涵体。通过透射电子显微镜在基质角膜细胞和内皮细胞中检测到疱疹病毒颗粒。免疫组化研究确定单纯疱疹病毒2型抗原在角膜上皮细胞、基质深层的角膜细胞和内皮细胞中同时表达。该患儿双侧进行性基质性角膜混浊的病因是单纯疱疹病毒2型角膜炎。在儿童进行性双侧角膜混浊的鉴别诊断中应考虑这种情况。
