Lim K L, Lowe J, Powell R J
Department of Immunology, University Hospital, Queens Medical Centre, Nottingham, UK.
Lupus. 1995 Apr;4(2):148-51. doi: 10.1177/096120339500400213.
Lymphocytic vasculitis (LV) characterises systemic lupus erythematosus (SLE) and this potentially reversible lesion, which may be subclinical, may imply overt systemic disease activity. Needle quadriceps muscle biopsy was performed in 26 unselected patients with SLE and the presence of LV in these muscle specimens was compared with SLE disease activity scored using the British Isles Lupus Assessment Group Index (BILAG). Ten of the 22 patients with active disease showed evidence of LV compared with none of the four patients with inactive disease. In the patient group with LV, significantly higher ESR and urine neopterin values were found with P = 0.002 and P = 0.02, respectively compared with patients without LV. Features of vasculitis (as defined by BILAG) were also significantly more common in these patients (P = 0.005). None of the other parameters, including creatine kinase, were significantly different between the two patient subgroups. Thus, LV in needle quadriceps muscle biopsy specimens is a further valuable marker of disease activity in patients with SLE and might provide histological evidence of a systemic vasculitic process in a group of patients with diverse clinical manifestations.
淋巴细胞性血管炎（LV）是系统性红斑狼疮（SLE）的特征表现，这种可能可逆的病变或许处于亚临床状态，可能意味着明显的全身疾病活动。对26例未经挑选的SLE患者进行了股四头肌针刺活检，并将这些肌肉标本中LV的存在情况与使用不列颠群岛狼疮评估组指数（BILAG）评分的SLE疾病活动度进行比较。22例活动期疾病患者中有10例显示有LV证据，而4例非活动期疾病患者均未显示。与无LV的患者相比，有LV的患者组中，血沉（ESR）和尿新蝶呤值显著更高，P值分别为0.002和0.02。血管炎特征（如BILAG所定义）在这些患者中也明显更常见（P = 0.005）。包括肌酸激酶在内的其他参数在两个患者亚组之间均无显著差异。因此，股四头肌针刺活检标本中的LV是SLE患者疾病活动的又一有价值标志物，可能为一组临床表现各异的患者提供系统性血管炎过程的组织学证据。
