Lasser V I, Raczynski J M, Stevens V J, Mattfeldt-Beman M K, Kumanyika S, Evans M, Danielson E, Dalcin A, Batey D M, Belden L K
New Jersey Medical School, Newark, USA.
Ann Epidemiol. 1995 Mar;5(2):156-64. doi: 10.1016/1047-2797(94)00060-7.
Identifying effective, nonpharmacologic means of preventing or significantly delaying the onset of hypertension would be a major advance in the primary prevention of cardiovascular disease. In the first phase of the Trials of Hypertension Prevention (TOHP I), adults with high-normal diastolic blood pressure were randomly assigned to one of seven nonpharmacologic interventions. Only weight loss and reduction of dietary sodium proved to be effective strategies for reducing blood pressure. The second phase of TOHP (TOHP II) will test the effectiveness of weight loss, reduction of dietary sodium, and their combination of lowering blood pressure and preventing the onset of hypertension over a 3- to 4-year follow-up period. This article describes the three interventions used in TOHP II, methods used to maintain continued participation in this long-term trial, and protocol enhancements designed to maximize intervention effectiveness.
确定有效的非药物手段来预防或显著延迟高血压的发病，将是心血管疾病一级预防的一项重大进展。在高血压预防试验（TOHP I）的第一阶段，舒张血压处于高正常范围的成年人被随机分配到七种非药物干预措施中的一种。只有体重减轻和减少饮食中的钠被证明是降低血压的有效策略。TOHP的第二阶段（TOHP II）将在3至4年的随访期内，测试体重减轻、减少饮食中的钠及其联合使用在降低血压和预防高血压发病方面的有效性。本文描述了TOHP II中使用的三种干预措施、用于维持对这项长期试验持续参与的方法，以及为使干预效果最大化而设计的方案改进措施。
