Wiener J S, Walther P J
Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Surg Oncol Clin N Am. 1995 Apr;4(2):257-76.
Sexually transmitted human papillomaviruses (HPV) are linked to both benign and malignant lesions of the genitourinary tract. Evidence links oncogenic HPV types with carcinomas of the penis and urethra. An association with other common sites of urologic malignancies (prostate, bladder) is controversial. Whereas the screening of sexually active females for HPV has received substantial attention, the presence of a potential male carrier state has received little scrutiny. Systemic immunotherapies based on expression of HPV-related proteins by infected or transformed human epithelia, however, may be possible in the near future.
性传播的人乳头瘤病毒（HPV）与泌尿生殖道的良性和恶性病变均有关联。有证据表明致癌性HPV类型与阴茎癌和尿道癌有关。与其他常见的泌尿系统恶性肿瘤部位（前列腺、膀胱）的关联存在争议。虽然对性活跃女性进行HPV筛查受到了广泛关注，但男性潜在携带者状态的存在却很少受到审查。然而，基于感染或转化的人类上皮细胞中HPV相关蛋白表达的全身免疫疗法在不久的将来可能成为现实。
