[拟除虫菊酯对大鼠脑突触体谷氨酸摄取的抑制作用]

[Inhibition of glutamate uptake in rat brain synaptosome by pyrethroids].

作者信息

Zhao X, Dai S, Chen G

机构信息

Department of Environmental Toxicology, Tongji Medical University, Wuhan.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Mar;29(2):89-91.

PMID:7796689

Abstract

In vitro studies showed deltamethrin (1 x 10(-7)-1 x 10(-4) mol/L) could inhibit 3H-DL-glutamate uptake in rat cerebral cortex and hippocampus synaptosome by 7.2%-21.5% and 10.4%-25.1%, respectively, with a dose-response pattern. But only in high-dose permethrin (1 x 10(-4) mol/L) can significantly reduce 3H-DL-glutamate uptake in rat hippocampus synaptosome. In addition, deltamethrin also can reduce 3H-DL-glutamate uptake in cerebellum and striatum of rats by 16.5% and 31.8%, respectively. It is suggested that both deltamethrin and permethrin, especially the former, can disturb the function of brain tissue in high-affinity-glutamate uptake with their alpha-cyano-group. So pyrethroids could play an important role in cerebral stimulation in mammals.

摘要

体外研究表明，溴氰菊酯（1×10⁻⁷ - 1×10⁻⁴mol/L）可使大鼠大脑皮层和海马突触体中³H-DL-谷氨酸摄取分别抑制7.2% - 21.5%和10.4% - 25.1%，呈剂量反应关系。但仅高剂量氯菊酯（1×10⁻⁴mol/L）可显著降低大鼠海马突触体中³H-DL-谷氨酸摄取。此外，溴氰菊酯还可使大鼠小脑和纹状体中³H-DL-谷氨酸摄取分别降低16.5%和31.8%。提示溴氰菊酯和氯菊酯，尤其是前者，可通过其α-氰基干扰脑组织高亲和力谷氨酸摄取功能。因此拟除虫菊酯可能在哺乳动物脑刺激中起重要作用。