Mullarkey M
Department of Medicine, University of Washington, Seattle 98104, USA.
Allergy Proc. 1995 Mar-Apr;16(2):81-4. doi: 10.2500/108854195778771462.
Over the last four or five years, there have been some serious attempts to look for alternatives to corticosteroids in the management of severe bronchial asthma. Rheumatologists and dermatologists long ago recognized the importance of replacing corticosteroids with other agents. Some agents such as methotrexate are now clearly established through multiple double-blind trials as being appropriate substitutes for corticosteroids, whereas other agents which have been investigated, such as cyclosporin, are very promising. Finally, a third group of agents, including troleandomycin (TAO), have been found to be totally inappropriate as possible substitutes for corticosteroids.
在过去的四五年里，人们一直在认真尝试寻找用于重度支气管哮喘治疗的皮质类固醇替代药物。风湿病学家和皮肤科医生早就认识到用其他药物替代皮质类固醇的重要性。一些药物，如甲氨蝶呤，现已通过多项双盲试验明确被确定为皮质类固醇的合适替代品，而其他一些经过研究的药物，如环孢素，前景也非常乐观。最后，包括醋竹桃霉素（TAO）在内的第三类药物已被发现完全不适合作为皮质类固醇的可能替代品。
