Spector S L
Allergy Research Foundation, Los Angeles, CA 90025, USA.
Curr Opin Pulm Med. 1997 Jan;3(1):23-9. doi: 10.1097/00063198-199701000-00005.
Various medications have been suggested as alternative therapy for oral corticosteroids in the treatment of asthma, due to the known adverse effects of oral corticosteroids. Examples of such medications include methotrexate, gold, cyclosporin A, hydroxychloroquine, and dapsone, all of which have a significant side-effect profile. Intravenous gammaglobulin therapy used as an immuno-modulator has little if any side-effects, but it is very costly. The antileukotrienes represent a safe class of medications that may be of particular benefit to certain subgroups of asthmatic patients. Antileukotrienes have become commercially available in other countries.
由于口服皮质类固醇存在已知的不良反应，各种药物已被建议作为口服皮质类固醇治疗哮喘的替代疗法。这类药物的例子包括甲氨蝶呤、金制剂、环孢素A、羟氯喹和氨苯砜，所有这些药物都有显著的副作用。用作免疫调节剂的静脉注射丙种球蛋白疗法几乎没有副作用，但成本非常高。抗白三烯药物是一类安全的药物，可能对某些哮喘患者亚组特别有益。抗白三烯药物在其他国家已上市。
