在一项双盲多中心试验中，新型抗抑郁药洛非帕明与丙咪嗪的比较。
Comparison of a new antidepressive, lofepramine, with imipramine in a double-blind multicentre trial.
作者信息
Woggon B, Angst J, Bleuler M, Dittmer L J, Heinrich K, Hippius H, Martens H, Seibel I
出版信息
Arch Psychiatr Nervenkr (1970). 1975 Dec 31;221(2):157-65. doi: 10.1007/BF00431051.
Lofepramine, an imipramine derivative, shows lower acute toxicity in animals when compared with desipramine and imipramine. Its anticholinergic effect is less pronounced than that of desipramine. In an open clinical trial lofepramine showed a marked antidepressive action. A double-blind multicenter trial of lofepramine v. imipramine, evaluated by means of the AMP system, showed a remarkable degree of concurrence with regards to the effects of those two products.
洛非帕明是一种丙咪嗪衍生物，与地昔帕明和丙咪嗪相比，在动物实验中显示出较低的急性毒性。其抗胆碱能作用比地昔帕明弱。在一项开放性临床试验中，洛非帕明显示出显著的抗抑郁作用。一项通过AMP系统评估的洛非帕明与丙咪嗪的双盲多中心试验表明，这两种产品的效果有显著的一致性。
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