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在一项双盲多中心试验中，新型抗抑郁药洛非帕明与丙咪嗪的比较。

Comparison of a new antidepressive, lofepramine, with imipramine in a double-blind multicentre trial.

作者信息

Woggon B, Angst J, Bleuler M, Dittmer L J, Heinrich K, Hippius H, Martens H, Seibel I

出版信息

Arch Psychiatr Nervenkr (1970). 1975 Dec 31;221(2):157-65. doi: 10.1007/BF00431051.

DOI:10.1007/BF00431051
PMID:779718
Abstract

Lofepramine, an imipramine derivative, shows lower acute toxicity in animals when compared with desipramine and imipramine. Its anticholinergic effect is less pronounced than that of desipramine. In an open clinical trial lofepramine showed a marked antidepressive action. A double-blind multicenter trial of lofepramine v. imipramine, evaluated by means of the AMP system, showed a remarkable degree of concurrence with regards to the effects of those two products.

摘要

洛非帕明是一种丙咪嗪衍生物，与地昔帕明和丙咪嗪相比，在动物实验中显示出较低的急性毒性。其抗胆碱能作用比地昔帕明弱。在一项开放性临床试验中，洛非帕明显示出显著的抗抑郁作用。一项通过AMP系统评估的洛非帕明与丙咪嗪的双盲多中心试验表明，这两种产品的效果有显著的一致性。

相似文献

1
Comparison of a new antidepressive, lofepramine, with imipramine in a double-blind multicentre trial.在一项双盲多中心试验中，新型抗抑郁药洛非帕明与丙咪嗪的比较。
Arch Psychiatr Nervenkr (1970). 1975 Dec 31;221(2):157-65. doi: 10.1007/BF00431051.
2
A double blind comparison of lofepramine, imipramine and placebo in patients with depression.洛非帕明、丙咪嗪与安慰剂治疗抑郁症的双盲对照研究。
Acta Psychiatr Scand. 1982 Aug;66(2):100-8. doi: 10.1111/j.1600-0447.1982.tb00918.x.
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[Clinical trial of lofepramine versus imipramine].
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[Double-blind comparative study on the effects of lofepramine and amitriptyline in depressive outpatients (author's transl)].洛非帕明与阿米替林对门诊抑郁症患者疗效的双盲对照研究（作者译）
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[Double-blind comparison of the effects of a new tricyclic antidepressant (Lofepramine) and a tetracyclic antidepressant (maprotiline)].
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[A double-blind comparison between mianserin and imipramine (author's transl)].
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A double-blind multicentre trial comparing mianserin with imipramine.一项比较米安色林与丙咪嗪的双盲多中心试验。
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Lofepramine and imipramine in unipolar depressed outpatients. A placebo controlled study.洛非帕明与丙咪嗪治疗单相抑郁门诊患者：一项安慰剂对照研究。
Acta Psychiatr Scand. 1982 Aug;66(2):109-20. doi: 10.1111/j.1600-0447.1982.tb00919.x.
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Comparative clinical evaluation of lofepramine and imipramine. Psychiatric aspects.洛非帕明与丙咪嗪的比较临床评估。精神科方面。
Acta Psychiatr Scand. 1977 Jan;55(1):10-20. doi: 10.1111/j.1600-0447.1977.tb00136.x.
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On the clinical response/serum level relationship for antidepressants II: Lofepramine and imipramine.抗抑郁药的临床反应/血清水平关系 II：洛非帕明与丙咪嗪
Psychopharmacol Bull. 1982 Apr;18(2):17-27.

引用本文的文献

1
Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
Drugs. 1989 Feb;37(2):123-40. doi: 10.2165/00003495-198937020-00003.

本文引用的文献

1
Biological and pharmacokinetic evidence for generic equivalence of three imipramine preparations: comparison with a new imipramine analogue.三种丙咪嗪制剂通用等效性的生物学和药代动力学证据：与一种新型丙咪嗪类似物的比较。
Acta Pharmacol Toxicol (Copenh). 1973;32(3):304-13. doi: 10.1111/j.1600-0773.1973.tb01475.x.
2
Chemistry and pharmacology of a new potential antidepressant. (N-methyl-N-[4-chlorobenzyl-methyl-3-(10,11-dihydro-5H-dibenz(b,f) azepin-5-yl)]-propylamine hydrochloride). (Leo 640, lopraminehydrochloride).一种新型潜在抗抑郁药的化学与药理学研究。（N-甲基-N-[4-氯苄基-甲基-3-(10,11-二氢-5H-二苯并(b,f)氮杂卓-5-基)]-丙胺盐酸盐）。（利奥640，盐酸洛普胺）
Arzneimittelforschung. 1970 Oct;20(10):1561-9.